Efeito do extrato etanólico de Simarouba versicolor em padrões reprodutivos de camundongos e no desenvolvimento embriofetal

Cunha, Ana Paula Gomes PereiraCavalcante, Ykro Talvanis DuarteOliveira, Moema Sousa DeFernandes, Rozeverter MorenoFernandes, Maria Zenaide De Lima Chagas Moreno

Simarouba versicolor has several proven biological activities, however little is known regarding effectson reproduction, so this study evaluated the effect of the ethanol extract of S. versicolor (EOH-Sv) embryofoetaldevelopment. It used to females pregnant randomly assigned into three groups receiving the extract of S.versicolor in doses of 5mg, 10mg and 20mg and a control group (-) received DMSO (3%) from the 8th to 12thday of gestation. The half of the fetuses was set at Bodian for visceral analysis, while the other half fixed informalin (5%) and subjected to alizarin red technique. The EOH-Sv at doses of 20 and 10mg caused abortionand death of the females and the dose of 5mg/kg was able to reduce the number of live fetuses compared tocontrols, there was an increase in the loss rate after implantation (46,03%) even with 90% of implantation. ThusEOH-Sv demonstrated maternal and fetal gestational toxicity.(AU)

1. reproductive toxicity
2. extrato etanólico
3. toxicidade reprodutiva
4. ethanol extract
5. Simarouba versicolor