O processo inflamátorio na formação do corpo luteo da égua
Pinto, Carlos R. F
Events leading to maturation of the equine preovulatory and ovulation resemble those present in an inflammatory reaction. Once ovulation takes place, luteinizing granulosa cells quickly continue to undergo functional and structural changes that results in a remarkable growth of the luteal gland and increasing output of progesterone. The developing corpus luteum requires the establishment of a robust development of extracellular matrix and vascular network (angiogenesis). This development and regulation is governed by several growth factors, cytokines, polymorphonuclear leukocytes, and prostaglandins that work in and autocrine and paracrine to achieve successful luteal function, especially if pregnancy is taking place. Most of the information available regarding early development of the corpus luteum and its regulation derive from studies in humans, ruminants and laboratory animals. Recently, considerable attention has been given to elucidating these events in the equine corpus luteum. While much of the available research conducted in other species can be extrapolated to equine species, it is critical that we continue to learn more about the intrinsic peculiarities about the CL formation and regulation in horses.(AU)
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