Periódicos Brasileiros em Medicina Veterinária e Zootecnia

p. 324-341

Effect of Curcuma zedoaria crude extract against tumor progression and immunomodulation

Carvalho, F. RVassão, R. CNicoletti, M. AMaria, D. A

The aim of the present work was to study the effect of the crude extract of Curcuma zedoaria on peripheral blood cells and tumor progression in C57Bl/6J mice injected with B16F10 murine melanoma cells. The intraperitoneal therapy showed a significant increase in total white and red blood cell counts, a decrease in peritoneal cell number and tumor volume reduction, whereas the oral administration revealed a noteworthy augmentation only in total leukocyte count. These results contribute to evaluate the importance of alternative treatments that employ phytotherapic compounds against tumor progression and its possible immunomodulation.(AU)

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