Periódicos Brasileiros em Medicina Veterinária e Zootecnia

p. 239-242

Comparação entre o efeito do Piroxicam e do Trocoxil, no controle da inflamação em neoplasias mamárias de cadelas utilizando a termografia

GREGHI, Julia RodriguesFERNANDES, Maíra PlanzoSCHINITZER, Josiana de FátimaYOKOMIZO, Débora NakayamaDI SANTIS, Giovana WingeterMARTINS, Maria Isabel Mello

Malignant mammary tumors are most prevalent neoplasms in bitches. Currently, it is known the influence of several factors and biological markers involved in tumors development, such as cyclooxygenase-2. Use of non-steroidal anti-inflammatory drugs appears as a promising adjuvant treatment. The aim of this study was to evaluate and to compare the effectiveness of piroxicam and Trocoxil® (mavacoxib) in reduce the peritumoral temperature. At random, it was selected 16 middle-aged bitches presenting mammary tumor according the routine of the Veterinary Hospital. On day 0, after clinical examination and thermography of both mammary chains, piroxicam was prescribed to group 1 (n=12) (0.3mg/kg, VO, SID, 10 days) and to group 2 (n=4) was prescribed Trocoxil® (2mg/kg, VO, single dose). After 10 days, the animals returned for further evaluation and the second thermography. The images were analyzed, tabulated and submitted to statistical analysis by the SigmaPlot® program in a simple t-test, considering p<0.05. The results indicated that Trocoxil® showed a better ability to reduce peritumoral temperature than piroxicam after 10 days of treatment (p=0.041), suggesting this drug with better efficiency in the adjuvant treatment of mammary neoplasms in bitches.(AU)

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