Periódicos Brasileiros em Medicina Veterinária e Zootecnia

p. 219-223

Avaliação da concentração do lactato desidrogenase em cadelas portadoras de neoplasias mamárias

PINHEIRO, Breno QueirozBARBOSA, Hélida Tainan SilvaMAGALHÃES, Francisco Felipe deSOUZA, Carmen Vládia Soares deALVES, Francisco Wesley da SilvaSILVA, Isaac Neto Góes daSILVA, Lúcia Daniel Machado da

The increase in lactate dehydrogenase (LDH) activity is associated with hypoxia due to the rapid proliferation of cancer cells and high metabolic demands. Few studies have evaluated the LDH concentration in canine mammary tumor (CMT). Thus, the objective of this work was to evaluate serum LDH concentrations in CMT and its association with prognostic factors. Thirty bitches participated in the work and were divided equally into two groups, with and without CMT. The average concentration of LDH was significantly higher in CMT (424.9±244.4U / L) compared to the control group (299.0±170.3 U / L) and its values were positively correlated with inflammation and / or macroscopic ulceration (r=0.6), tumor size (r=0.5), histopathological grade (r=0.6), metastatic lymph node (r=0.7) and clinical stage (r=0.5).(AU)

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