COX-2 and TGF-ß expression in proliferative disorders of canine prostate

Marcela M.P. RodriguesGiovana W. Di SantisVeridiana M.B.D. de MouraRenée L. Amorim

COX-2 and TGF-_ expression was determined in order to correlate non-neoplastic lesions, preneoplastic lesions and carcinoma in the prostate of dogs. The results show that neoplastic and preneoplastic lesions express more COX-2 and TGF-_ when compared to carcinomas, which suggests these proteins may cooperate in the process of prostate tumorigenesis.(AU)

1. dog
2. carcinoma prostate
3. TGF-ß
4. preneoplastic lesions
5. COX-2