Impacts of maternal nutritional plane on umbilical artery hemodynamics, fetal and placentome growth in sheep
Lekatz, L ALuther, J SCaton, J SVonnahme, K A
The present study aimed to examine the impact of maternal nutritional plane on umbilical hemodynamics. E wes (n = 15) were ass igned to 1 of 3 dietary treatments [ control (CON; 100% of N RC requirements), restricted (RES; 60% of CON) or overfed ( OVR ; 140% of CON) ] beginning on day 40 of gestation . Umbilical artery hemodynamics, fetal growth and placentome growth were measured on da y s 40, 45, 52, 80, 94 and 108 of gestation by Doppler ultrasonography . The percentage change in umbilical artery pulsatility and resistance ind ices remained steady through day 80 of gestation, and then decreased (P < 0. 03 ) by day 108 of gestation . Moreover , p lane of nutrition affected (P < 0. 03 ) the percentage change in pulsatility index from day 40 , with RES ewes having a greater (P < 0.03 ) change compared to CON ( 16. 7 ± 7.5 vs . - 15.6 ± 7.5 %) , with OVR being intermediate ( 3.2 ± 7.5 %). Fetal biparietal and abdominal diameter s increased (P < 0.01) throughout gestation, and f etal heart rate decreased (P < 0.01) from day 52 to 108 of gestation. Placentome diameter increased (P < 0.01) through day 80 of gestation, was similar (P > 0. 05 ) on day s 80 and 94 of gestation, and then decreased (P < 0.01) by day 108 of gestation. Maternal p lane of nutrition can impact umbilical resistance indices, and ultimately may impact blood flow to the fetus.(AU)
Texto completo