Periódicos Brasileiros em Medicina Veterinária e Zootecnia

The relationship between insulin resistance and type II ketosis in dairy cows

Cuiyu, ZhangChang, ZhaoJiang, ZhangCheng, XiaYou, Zhang Hong

Background: Cows in perinatal period are prone to ketosis, characterized by increased ketone bodies and decreased bloodsugar. Study found that cows with type II ketosis had higher blood glucose levels. This type of ketosis exhibits insulinresistance and impaired glucose tolerance that are similar to type 2 diabetes. The purpose of this study was to investigatethe role of insulin resistance(IR) in type II ketosis in dairy cows.Materials, Methods & Results: In one intensive cattle farm, eight cows with ketosis and eight healthy cows that were 14-21 days postpartum were selected. The plasma of experimental dairy cows was collected and tested for the concentrationof glucose concentration. Glucose tolerance of blood glucose levels in 120 min was used as the cut-off point to divide thedairy cows into three groups: the abnormal glucose tolerance ketosis group (TH), the normal glucose tolerance ketosis(TL), and the healthy control group. Simultaneously, the indexes of plasma liver function, oxidative stress, and insulinresistance were detected. The results showed that after intravenous glucose injection, there was no significant differencein blood glucose concentration between the TL and control group, while the blood glucose levels in the TH group werealways higher than in the other two groups. The insulin sensitivity index (RQUICKI) value was significantly lower in theTH group than in the other two groups. Liver function abnormalities in the TH group were more severe than in the TL andcontrol group. Oxidative stress was higher in the TH group than in the TL and control groups...(AU)

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