Periódicos Brasileiros em Medicina Veterinária e Zootecnia

Avaliação pós-cirúrgica do impacto analgésico do tramadol epidural, quando associado à levobupivacaína, em cadelas submetidas à mastectomia e à ovariohisterectomia

Mangabeira, Ravena de OliveiraReis, Herbert Aragão dosCoelho, Ana Paula GóesSilva, Laís PereiraLima, Alessandra Estrela da SilvaBarbosa, Vivian Fernanda

Background: Mammary tumors are the most common neoplasms in female dogs. Surgical removal of the mammary glandchain is considered the standard treatment and is usually performed along with ovariohysterectomy (OH) to suppressovarian hormonal influence. Mastectomies cause moderate to severe pain and require preferential multimodal analgesicprotocols. The aim of this study was to compare the postoperative analgesic efficacy and the recovery times on femaledogs undergoing mastectomies and OH between those treated with epidural levobupivacaine alone and those treated withassociated doses of tramadol and anesthetized with propofol.Materials, Methods & Results: Eighteen female dogs were pretreated with acepromazine (0.03 mg/kg), using propofol(4 mg/kg) for induction and anesthesia maintenance. The dogs were randomly divided into three groups (n = 6) treatedwith epidural anesthesia with levobupivacaine alone at 1.5 mg/kg (GL) or associated with tramadol at doses of 2 mg/kg(GLT2) or 4 mg/kg (GLT4). After anesthesia, the mean propofol infusion rate for each group were calculed. During thepostoperative period, the degree of analgesia according to the University of Melbourne Pain Scale for 6 hours were determined, considering seven time points for evaluation (M30, M60, M90, M120, M180, M240, and M360). Supplementalanalgesia with morphine (0.5 mg/kg) to those dogs with scores ≥13 were provided. During the recovery period, the timeintervals between the end of anesthesia, and the following events: extubation (EX), the first head movement (MC), and theestablishment of sternal (PE) and quadrupedal (PQ) positions were measured. Data were subjected to the Friedman testfor analysis of non-parametric variables within the same group and to the Mann–Whitney test for independent variables,comparing the mean scores between groups (statistical significance was set at P < 0.05). In the GL group, a higher meanpropofol infusion rate than in either the ...(AU)

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