Adenocarcinoma pulmonar sólido primário em cão

Oliveira, Mariana CorreiaCosta, Samay Zillmann RochaPires, Ana Paula de CastroGonçalves, TaïnaFernandes, Júlio IsraelCamargo, Rodolfo Bettio Pires deNogueira, Vivian de Assunção

Background: In veterinary medicine, although primary lung tumors are rare compared to metastatic malignant neoplasms,an increase in the number of primary lung tumors in dogs has been reported in the past decades. Consequently, identifyingepidemiological, clinical, and pathological features of these neoplasms is essential for early and precise diagnosis. Thispaper aimed to report a case of a non-metastatic primary solid pulmonary adenocarcinoma in a dog and review the clinical,pathological, and immunohistochemical aspects of this neoplasm.Case: An 8-year-old female Cocker Spaniel was admitted to the Small Animals Veterinary Hospital of the Rural FederalUniversity of Rio de Janeiro (Brazil) with a history of progressive weight loss and clinical dyspnea. Physical examinationrevealed the following: body temperature, 38.7ºC; capillary refill time, one second; heart rate, 104 beats/min; respiratoryrate, 40 breaths/min; pallor mucosa; blood glucose, 133 mg/dL; and body score, 2 (1-9). A thoracic radiograph revealeda diffuse radiopaque pattern of the pulmonary parenchyma, pleural effusion, and a large mass that extended through bothhemithoraces. An ultrasound-guided cytological examination was performed and displayed moderate cellularity in a bloodybackground. Cells presented distinct cell borders, large bluish cytoplasm, round hyperchromatic or vesicular nuclei, andevident nucleoli. Three months after the first clinical consultation, the dog’s state kept deteriorating and the owner optedfor the euthanasia. Autopsy of the lungs showed multiple, poorly defined, coalescent nodules with an average size of20.0×15.0×10.0 cm. The nodules occupied roughly 70% of the pulmonary...(AU)

1. lung carcinoma
2. carcinoma pulmonary
3. solid
4. immunohistochemistry
5. sólido
6. neoplasia
7. imunohistoquímica