Oxidative Stress and Changes on the Adenosinergic System of Cats Infected by Feline Leukemia Virus (FeLV)
Biezus, GiovanaAssis Casagrande, RenataDellaméa Baldissera, MatheusBianchi Bottari, NathieliEduardo Ferian, PauloMaria Morsch, VeraRosa Chitolina Schetinger, MariaAline Withoeft, JéssicaHenrique Hasckel da Silva Pereira, LeonardoSchafer da Silva, AleksandroMachado, Gustavo
Background: The feline leukemia virus (FeLV) is clinically important retroviruses that infect domestic and wild feline worldwide, affecting more than 3 million cats representing a great risk for premature death. Some studies have demonstrated that oxidative stress, as well as the adenosinergic system, exert an important role in the pathogenesis of viral diseases. Oxidative stress is considered a disturbance in the antioxidant/oxidant status in favor of the excessive generation or lower removal of free radicals. Therefore, the aim of this study was to evaluate whether changes on the adenosinergic system and oxidative stress occurred in cats positives for feline leukemia virus (FeLV).Materials, Methods & Results: Forty-nine serum samples of cats (between 4 months and 13 years of age) seen at the Veterinary Hospital of the University of Santa Catarina State (UDESC - Lages, SC, Brazil) were used. Blood samples were collected from the jugular vein and stored in tubes without anticoagulant to obtain serum. An aliquot was used to detect both viral infections using the kit SNAP FIV/FeLV, that detects the p27 protein from FeLV and antibodies against the p24 protein from FIV. The test was performed according the manufactures recommendations. Based on this result, this study involved 20 FeLV negative cats, 20 FeLV positive symptomatic cats, and 9 FeLV positives asymptomatic cats. Ser
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