The impacts of prebiotic and feed restriction on serum biochemical parameters of broilers under microbial stress caused by Salmonella enterica
Maddahian, AliSadeghi, Ali AsgharShawrang, ParvinAminafshar, Mehdi
Background: Feed restriction is limiting feed in one period of breeding and has advantages such as decreasing ascite and sudden death syndrome. During feed restriction, colonization of pathogens . A great number of researches have shown the positive effects of feed restriction or prebiotic on performance in separate, but few have been done on their effects on blood parameters, especially in pathogen challenging condition. The aim of this study was to investigate the impacts of prebiotic and feed restriction, alone and together, on serum biochemical parameters of broilers under microbial stress caused by Salmonella enterica challenge.Materials, Methods & Results: A total of 320 male broilers (Ross 308) at a2×2×2 factorial arrangement in randomized complete block design were divided into eight treatment groups with four replicates per each. The impact of main effects of prebiotic, feed restriction and Salmonella challenge and their interactions on serum parameters were measured at days 21 and 42 of age. The addition of prebiotic to diet decreased serum cholesterol (P < 0.01) and low density lipoprotein (P < 0.01), but increased high density lipoprotein (P < 0.05), total protein (P < 0.05) and albumin (P < 0.05) at day 42 of age. The feed restriction increased triglyceride (P < 0.001) at day 21 of age. The Salmonella challenge decreased total protein (P < 0.01) and albumin (P < 0.01) at day 21 of age. Interaction between prebiotic and feed restriction on serum high density lipoprotein (P < 0.05) at day 42 of age, and the interaction between feed restriction and Salmonella challenge on serum high density lipoprotein (P < 0.05) and interaction among prebiotic, feed restriction and Salmonella challenge on serum glucose (P < 0.05) at day 21 of age were significant. Serum uric acid was not affected by the main effects and their interactions (P > 0.05).[...](AU)
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