Periódicos Brasileiros em Medicina Veterinária e Zootecnia

Comparative plasma dispositions of meloxicam and carprofen following oral administration in dogs

Karademir, UmitGokbulut, CengizAkar, Ferda

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are used extensively in several domestic animal speciesfor the treatment of a range of musculo-skeletal disorders and soft tissue injuries or inflammatory conditions. These drugshave antipyretic, anti-inflammatory and analgesic properties. Meloksikam (MLX) and carprofen (CRP) are two of theNSAIDs most commonly used by oral administration, which is the preferred route for the treatment of chronic pain andinflammation in dogs. The aim of the present study was to determine the pharmacokinetic properties of CRP and MLX inhealthy dogs following oral administration at the doses of 2 mg/kg and 0.2 mg/kg bodyweight, respectively.Materials, Methods & Results: A total of 12 client-owned, cross-bred bitches, 2-5 years old and weighing 15-20 kg wereused in the study. The animals were allocated into two groups of six such that the mean weight of animals in each groupwas similar. In Group I, CRP was given orally at a dose of 2 mg/kg and in Group II, MLX was given orally at a dose of 0.2mg/kg. Blood samples were collected one day prior to drug administration and 1, 2, 3, 4, 5, 6, 7, 8, 10, 12, 16, 24, 32, 40,48, 56, 72 and 96 h post-treatment. Samples were centrifuged at 3000 g for 20 min and plasma was transferred to plastictubes. Heparinized drug-free blood samples for analytical method development and validation process were collected fromdogs not included in the study. All the plasma samples were stored at -20oC until estimation of drug concentrations withall analyses completed within one month of sampling and they were analysed by high-performance liquid chromatography(HPLC). The terminal half-life of MLX (t1/2 = 37.91 ± 9.15 h) was significantly longer compared with that of CRP (t1/2 =17.02 ± 6.95 h). In addition, CRP was absorbed faster (tmax = 2.20 h) from gastrointestinal system and reached the peakplasma...(AU)

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