Periódicos Brasileiros em Medicina Veterinária e Zootecnia

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B cell lymphoma with mott cell differentiation in a dog

Guimarães, Lorena Lima BarbosaFredo, GabrielaHesse, Kivia LunardelliRaymundo, Djeison LutierPeixoto, Paulo VargasDriemeier, DavidSonne, Luciana

Background: B cell lymphoma with Mott cell differentiation is rarely reported in dogs. This neoplasms has been diagnosed in the gastrointestinal tract and therefore is considered the differential diagnosis of obstruction by foreign body, enteritis and other intestinal neoplasms. The objective of the present study was to describe macroscopic, microscopic and immunohistochemical findings of a B cell lymphoma with Mott cell differentiation in the gastrointestinal tract of a dog.Case: A 7-year-old male German Shepherd dog was referred to necropsy with a mass 12 cm in diameter in the ileum-cecocolic junction, compromising mesenteric lymph nodes. Cytology showed two types of lymphoid cells. Approximately 80-90% of cells were round, with large cytoplasm containing numerous basophilic inclusion corpuscles, round nuclei, condensed chromatin, inconspicuous nucleoli, moderate anisokaryosis and marked anisocytosis. The other cells were round, with scarce basophilic cytoplasm, round nuclei, condensed chromatin and inconspicuous nucleoli. Mild anisokaryosis and anisocytosis and mitotic figures were sometimes identified. Histology revealed the predominance of round cells, with large cytoplasm containing numerous eosinophilic corpuscles (Russel bodies). Neoplastic cells were PAS and PTAH-positive, and toluidine blue-negative. Immunohistochemistry revealed positive immunoreactivity to antibodie...(AU)

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