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Periódicos Brasileiros em Medicina Veterinária e Zootecnia

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TNF- and IL-10 modulate CK and CK-MB activities in naturally infected dogs by Leishmania infantum

Cláudio Carneiro de Freitas, JoséLeal Lima, AdamTamára de Araújo Rodriguês, CarlaKarlo Gama de Almeida, GianJonas Lemos Santos, GlaucoMendes Roatt, BrunoBarbosa Reis, AlexandreCélia Sousa Nunes-Pinheiro, Diana

Background: Canine visceral leishmaniasis (CVL) is a multisystem inflammatory disease caused by the Leishmania genus protozoa, characterized by increased production of pro-inflammatory mediators. The parasite presence has been reported in various organs and tissues, such as bone marrow, lymph nodes, spleen, liver and skin, in addition the cardiac muscle. Cardiac muscle lesions provide the substances release, among which we can mention the creatine kinase (CK), its MB subunit (CK-MB) and troponin. The changes that cause these injuries depend not only of the parasite presence, but also the increased concentrations of proinflammatory cytokines. Although most studies focus on the proinflammatory cytokines action, regulatory cytokines of the inflammatory process has gained evidence in the immune response to the Leishmania infantum and can be directly associated with the cardiac damage pathogenesis. Therefore, this study aimed to evaluate the TNF- and IL-10 serum levels in naturally infected dogs by L. infantum and relates them to cardiac biomarkers, in the different clinical forms of disease.Materials, Methods & Results: A total of 30 adult dogs were used, being 10 negative (ND) and 20 positive for CVL. All seropositive animals were subjected to clinical examination, observing the presence of characteristic clinical signs of disease, being divided into two groups: asymptomatic

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