Periódicos Brasileiros em Medicina Veterinária e Zootecnia

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Amiodarone may prevent the tilmicosin-caused lethal toxicity

Er, AyseTras, Bunyamin Guln, GulDik, Burak

Background: Tilmicosin is widely used in veterinary medicine and its accidental overdose by injection may cause death via causing negative inotropy and positive chronotropy in both the treated animal and the veterinarian. In addition, there is no any antidote against to tilmicosin-caused death. Amiodarone blocks some channels in the heart, but it has much complex effect including vagotonic, bradycardic etc on the heart. Considering vagotonic and bradycardic effects of amiodarone, it has been hypothesised that amiodarone may prevent tilmicosin-caused death. The aim of this study was to determine the effect of amiodarone on the survival rate of rats in tilmicosin-caused lethal toxicity.Materials, Methods & Results: Twenty female Wistar rats (body weight: 288 ± 33.8 g, age: 7-8 months) were used in this study. The study protocol was approved by the Ethical Committee. Rats received food and water ad libitum. The rats were divided into two groups containing 10 rats each. Rats in Group 1 were administered 360 mg/kg of tilmicosin in a single subcutaneous injection. Rats in Group 2 were administered 25 mg/kg of amiodarone via the tail vein at 8. min after the single subcutaneous injection of tilmicosin in a dose of 360 mg/kg. After the injections, deaths were recorded at 0, 2, 6, 10, 12 and 24 h. At the end of the 24-h period, survival/death ratio was analysed by the Chi-square tes

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