Periódicos Brasileiros em Medicina Veterinária e Zootecnia

p. 01-04

Transmissible venereal tumor treated with autohemotherapy

Oliveira Drumond, KarinaMaria Quessada, AnaMaria Medeiros de Sousa Silva, SilvanaAssis Lima Costa, Franciscodos Santos Silva, LucileneAlves de Pinho, FlavianeRamon Fernando Barbosa Lopes, Rallyson

Background: Transmissible venereal tumor (TVT) is a neoplasm of round cells, that affects exclusively the canine specie. The etiology of the tumor is unknown, but the hystiocitic hipothesis is the more accepted. It is transmitted principally by the venereal form, but the inplant of cells can cause the disease. The clinic signs of the neoplasia are typical and include tumoral friable mass (in shape of cauliflower), that bleed easily. The most common localization is external genitalia, but the tumor can appears in skin surface and other organs. TVT grows rapidly (progressive phase) after transplantation, followed by a static phase (without cell proliferation) and then may regress spontaneously (stage of regression). The regression of the neoplasia is associated with increased infiltration of T lymphocytes and macrophages in the tumor and characterized by increased apoptosis of tumor cells and fibrosis. The diagnosis of TVT is usually done by the physical aspect of the tumor, and confirmed by cytology or histopathology. TVT can be prevented by castration of the animals. The treatment of TVT is usually performed with vincristine, which has side effects, requires care in its application, and has a relatively high cost. Thus, new therapeutic low-cost alternatives are suggested, as is the case of autohemotherapy. The autohemotherapy technique consists of administration of autologous w

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