Periódicos Brasileiros em Medicina Veterinária e Zootecnia

p. 01-04

Hepatopatia crônica associada ao acúmulo de cobre em um cão da raça American Pitbull Terrier

da Silva Mottin, TatianeAndreatta Torelly Pinto, LucianaGomes Pöpp, AlanSchafrum Macedo, Alinedos Santos Dal-Bó, ÍsisBettim Bandinelli, MarceleGuimarães Gerardi, DanielDriemeier, DavidAfonso de Castro Beck, Carlos

Background: The liver plays a variety of essential biochemical functions such as the metabolism of carbohydrates, proteins, lipids and vitamins, the maintenance of blood glucose and bile acids synthesis. Hepatic insuffi ciency occurs when 70 to 80% of the functional liver mass is committed the liver is unable to metabolize substances on the circulation. In some cases, chronic liver disease may be associated with copper accumulation, which may occur by increased dietary intake, faults in hepatic copper metabolism or liver diseases that cause colestase. The purpose of this paper is to report a case of chronic liver disease associated with copper accumulation in a 8-month-old American Pit Bull Terrier.Case: An American Pitbull Terrier was referred to the Veterinary Teaching Hospital of the Federal University of Rio Grande do Sul with a history of abdominal distension, decreased appetite, vomiting, diarrhea, weight loss and exhaustion. On physical examination the animal presented ascites and dehydration and laboratory tests were suggestive of active liver disease. Supportive care was provided. The patient was prescribed ranitidine (2 mg/kg) VO BID for 7 days, metoclopramide (0.3 mg/kg) VO BID also for 7 days and furosemide (1 mg/kg) PO BID until further instructions while awaiting for test results. The next appointment was scheduled for ten days later but the owner came back for co

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