Periódicos Brasileiros em Medicina Veterinária e Zootecnia

p. 01-11

Antimicrobial activity of copper (II) complex with 1,2-bis [(1,3-diphenylpyrazol-4-yl)methyl] diaminoethane

Suvajdzic, LjiljanaLeovac, VukadinJoksovic, MilanBogdanovic, GordanaKojic, VesnaVujic, NemanjaMrdja, TatjanaKocic, Branislava

Background: Multi-resistant strains multiply daily, populate farms, hospitals and other ecological niches around the world, and cause serious infections in animals and humans, often leading to a fatal outcome. Researchers of all profiles are investigating intensively to fi nd new substances with antimicrobial activity. In the period between 1981 and 2002, 163 new chemical compounds were approved for use as drugs. Synthesized compounds have become much more interesting than the natural ones in the production of new antimicrobial agents. Some of these synthesized compounds are Copper (II) complex. The antimicrobial properties of copper were known in ancient Egypt (2000 BC), where it was used to sterilize water and wounds. Copper is still interesting for todays research. Materials, Methods & Results: Antimicrobial activity was tested using a microdilution method according to Clinical and Laboratory Standards Institute. The percentage of surviving bacteria was calculated in comparison to the number of bacteria placed in each well. Based on these results, using the Excel software package from Microsoft Office 2007, graphs were generated that showed the percentage of surviving bacteria depending on the corresponding effective concentrations of the tested substance. The function, which was used to approximate the experimental results, was determined using the Power Trendline supp

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