Periódicos Brasileiros em Medicina Veterinária e Zootecnia

p. 245-249

Serum and Urinary C-Reactive Protein Concentrations in Dogs with Leptospirosis

Tostes Oliveira, SimoneBelle Messick, JoanneWelker Biondo, AlexanderPires Santos, AndreaMárcia de Sá Guimarães, AnaSidi Mohamed, AhmedAntônio Simões Pires Neto, JoséLarruscaim Dalmolin, MagnusHilario Dias González, Felix

Background:  : : Leptospirosis is a bacterial disease caused by pathogenic strains of Leptospira, which may affect human beings and a wide range of both domestic and wild animals. The disease in dogs is still a challenge for clinicians, since definitive diagnosis may be reached only few days after overt clinical signs. Besides that, dogs with leptospiruria have zoonotic risk, making development of rapid screening tests crucial for early diagnosis of disease. C-reactive protein is a positive acute phase protein, a nd in the dog a strong and fast response is expected after any tissue injury. The aim of this study was to evaluate serum and urinary C-reactive protein as potential early indicators of leptospirosis in dogs, and its association with clinical serum biochemistry, complete blood count (CBC) and clinical outcome. Materials, Methods & Results: A total of 62 dogs with risk factors and/or clinical signs of leptospirosis were prospectively obtained and included in this study. Definitive diagnosis was based on serology, using the microscopic agglutination test (MAT) against 13 serovars, and on a specific polymerase chain reaction (PCR) in blood or urine, using the primers sets G1/G2 and B64I/B64II, which amplify DNA of pathogenic leptospires. Clinical serum biochemistry included creatinine, urea, alanine aminotransferase, alkaline phosphatase, creatine kinase and albumin.

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