PPARG expression in colorectal cancer and its association with staging and clinical evolution

Villa, Andre Luiz PrezottoParra, Rogério SerafimFeitosa, Marley RibeiroCamargo, Hugo Parra deMachado, Vanessa ForestoTirapelli, Daniela Pretti da CunhaRocha, José Joaquim Ribeiro daFeres, Omar

Purpose To evaluate the gene expression of peroxisome proliferator activated receptors gamma (PPARG) in colorectal tumors and to correlate this data with clinical variables of the patients. Methods We analyzed the gene expression of PPARG in 50 samples of colorectal tumors using real-time reverse transcription polymerase chain reaction, and 20 adjacent normal tissue samples as control. The results of these quantifications were correlated with the respective patients medical records clinical information. Results PPARG expression was not different in the tumor tissue compared to the control tissue. Patients older than 60 years, histological type with mucinous differentiation, more advanced staging at the time of diagnosis, and patients who evolved with recurrence of the disease or death did not present higher PPARG expression. Conclusion Expression of PPARGD was not associated with worse prognosis.(AU)

1. Prognosis
2. Colorectal neoplasms
3. Drug therapy
4. Biomarkers