Effect of ethyl acetate extract of usnea longissima on esophagogastric adenocarcinoma in rats

Mammadov, RenadSuleyman, BahadirAltuner, DurduDemirci, ElifCetin, NihalYilmaz, AdnanBaykal, HuseyinAlpcan, HilalTurumtay, Emine AkyuzSuleyman, Halis

Purpose:To investigate the effects of the EtOAc extract of U. longissima which is uninvestigated previously on esophagogastric cancer induced in rats with N-methyl-N-nitro-N-nitrosoguanidin (MNNG).Methods:The anticancer activity of EtOAc extract of U. longissima was examined in the esophagogastric adenocarcinoma models induced in rats with MNNG. EtOAc extract of U. longissima, 50 and 100 mg/kg oral doses were administered once daily for six months. MNNG induced differentiated and undifferentiated type adenocarcinomas in the esophageal and gastric tissues of rats.Results:EtOAc extract of U. longissima obtained from U. longissima prevented gastric and esophageal cancerogenesis induced in rats with MNNG. EtOAc extract of U. longissima did not have a lethal effect at doses of 500, 1000 and 2000 mg/kg. The prominent anticarcinogenic activity of EtOAc extract of U. longissima 50 and 100 mg/kg suggests that it is not toxic and it is selective to the cancer tissue.Conclusion:This information may shed light on clinical implementation of EtOAc extract of U. longissima in future.(AU)

1. Acetates
2. Usnea
3. Rats
4. Adenocarcinoma