Use of fibrinogen and thrombin sponge in pediatric split liver transplantation

Vicentine, Fernando Pompeu PizaGonzalez, Adriano MiziaraBeninni, Barbara BurzaAzevedo, Ramiro Anthero deLinhares, Marcelo MouraGoldenberg, AlbertoLopes Filho, Gaspar de JesusMartins, Jose LuizSalzedas Netto, Alcides Augusto

Purpose: To analyze the use of this sponge in pediatric patients undergoing split-liver transplantation. Methods: Retrospective study, including 35 pediatric patients undergoing split-liver transplantation, divided into two groups according to the use of the sponge: 18 patients in Group A (no sponge) and 17 in Group B (with sponge). Results: The characteristics of recipients and donors were similar. We observed greater number of reoperation due to bleeding in the wound area in Group A (10 patients - 55.5%) than in Group B (3 patients - 17.6%); p = 0.035. The median volume of red blood cells transfused in Group A was significantly higher (73.4 ± 102.38 mL/kg) than that in Group B (35.1 ± 41.67 mL/kg); p = 0.048. Regarding bile leak there was no statistical difference. Conclusion: The use of the human fibrinogen and thrombin sponge, required lower volume of red blood cell transfusion and presented lower reoperation rates due to bleeding in the wound area.(AU)

1. Fibrinogen
2. Homeostasis
3. Thrombin.
4. Liver Transplantation