Influence of remote ischemic conditioning and tramadol hydrochloride on oxidative stress in kidney ischemia/reperfusion injury in rats
Oliveira, Rita de Cássia Silva deBrito, Marcus Vinicius HenriquesRibeiro Júnior, Rubens Fernando GonçalvesOliveira, Leonam Oliver DurvalMonteiro, Andrew MoraesBrandão, Fernando Mateus ViegasCavalcante, Lainy Carollyne da CostaGouveia, Eduardo Henrique HerbsterHenriques, Higor Yuri Bezerra
Purpose: To evaluate the effects of tramadol hydrochloride associated to remote ischemic perconditioning on oxidative stress. Methods: Twenty five male rats (Wistar) underwent right nephrectomy and were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of renal ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during kidney ischemia; Tramadol group (T) treated with tramadol hydrochloride (40mg/kg); remote ischemic perconditioning + Tramadol group (Per+T) with both treatments. Oxidative stress was assessed after 24 hours of reperfusion. Results: Statistical differences were observed in MDA levels between I/R group with all groups (p 0.01), in addition there was difference between Tramadol with Sham, Per and Per+T groups (p 0.05), both in plasma and renal tissue. Conclusion: Remote ischemic perconditioning was more effective reducing renal ischemia-reperfusion injury than administration of tramadol or association of both treatments.(AU)
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