Periódicos Brasileiros em Medicina Veterinária e Zootecnia

p. 949-955

Perconditioning associated to hypertonic saline solution on liver function improvement after ischemia/reperfusion injury

Ribeiro Júnior, Rubens Fernando GonçalvesCouteiro, Rodrigo ParacampoMonteiro, Andrew MoraesRodrigues, Ivone Aline da SilvaCavalcante, Lainy Carollyne da CostaGouveia, Eduardo Henrique HerbsterGalvão, Lucas NascimentoLopes, Luiz Renato OliveiraYasojima, Edson YuzurBrito, Marcus Vinicius Henriques

Purpose: To evaluate the effects of hypertonic saline solution associated to remote ischemic perconditioning in liver ischemia/reperfusion injury in rats. Methods: 25 male rats (Wistar) were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of liver ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during liver ischemia; Hypertonic saline solution group (HSS) treated with hypertonic saline solution (4ml/kg); Remote ischemic perconditioning + Hypertonic saline solution group (Per+HSS) with both treatments. Results: Per+HSS group showed a lower degree of liver dysfunction in relation to I/R group, whereas the technique of remote ischemic perconditioning isolated or associated with saline solution significantly improved liver function and reduced histological damage. Conclusion: Remote ischemic perconditioning associated or not to saline solution promoted reduction of acute liver injury induced by ischemia/reperfusion.(AU)

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