The beneficial effects of Montelukast against 2, 3, 7, 8-tetrachlorodibenzo- p -dioxin toxicity in female reproductive system in rats

Melekoglu, RaufCiftci, OsmanCetin, AslıBasak, NeseCelik, Ebru

PURPOSE:To determine the toxic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on reproductive system and the beneficial effects of Montelukast (ML) with histological and biochemical analysis.METHODS:Rats were randomly divided into four equal groups (control, TCDD, ML and TCDD+ML). Tissue samples were collected on day 60 and oxidative status and histological alterations were analyzed.RESULTS:The results showed a significant increase in oxidative and histological damage on uterine and ovarian tissues. Otherwise, the oxidative and histological damages caused by TCDD were prevented with ML treatment.CONCLUSION:The toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on female reproductive system were reversed with Montelukast treatment. Therefore, we claimed that ML treatment might be useful for TCDD toxicity.(AU)

1. tetrachlorodibenzodioxin
2. ovary
3. uterus
4. leukotriene antagonists
5. oxidative stress