Periódicos Brasileiros em Medicina Veterinária e Zootecnia

p. 557-563

The beneficial effects of Montelukast against 2, 3, 7, 8-tetrachlorodibenzo- p -dioxin toxicity in female reproductive system in rats

Melekoglu, RaufCiftci, OsmanCetin, AslıBasak, NeseCelik, Ebru

PURPOSE:To determine the toxic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on reproductive system and the beneficial effects of Montelukast (ML) with histological and biochemical analysis.METHODS:Rats were randomly divided into four equal groups (control, TCDD, ML and TCDD+ML). Tissue samples were collected on day 60 and oxidative status and histological alterations were analyzed.RESULTS:The results showed a significant increase in oxidative and histological damage on uterine and ovarian tissues. Otherwise, the oxidative and histological damages caused by TCDD were prevented with ML treatment.CONCLUSION:The toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on female reproductive system were reversed with Montelukast treatment. Therefore, we claimed that ML treatment might be useful for TCDD toxicity.(AU)

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