The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in rats

Camargo, Cristina PiresFernandes, Felipe AlexandreLee, Michel Hyo MiSilva, Luiza Campos MoreiraBesteiro, Julio MoraisGemperli, Rolf

PURPOSE:To evaluate the effect of Botulinum Toxin A in different time of tobacco exposure.METHODS:60 male, Wistar rats were divided into two tobacco exposure groups: a 2- month or a 4-month regimen. After this period, these two groups were subdivided as two: saline solution(SS) or botulinum toxin A(Bonta), at the time of the surgery. Seven days before the SS or Bonta injection, the animals were submitted to a random flap (3x10cm). On the seventh postoperative day, all animals were assessed for total flap area, viable area, and the viable/ total area ratio.RESULTS:This study showed a difference between groups 2-month saline vs. BontA injection (p=0.04); groups 4-month saline vs. BontA injection (p=0.001); groups 2-month saline vs. 4-month BontA (p=0.003), and, between groups 2- month BontA vs. 4-month saline(p=0.03).CONCLUSIONS:Botulinum Toxin A increased random flap viability in tobacco-exposed rats. Two months of tobacco exposure had the same effect as exposure for four months.(AU)

1. surgical flaps
2. type A
3. Botulinum toxins
4. tobacco
5. survival
6. rats