Progressive loss of E-cadherin immunoexpression during cervical carcinogenesis
Cavalcante, José RooseveltSampaio, João Paulo AguiarMaia Filho, João Tarcísio AlvesVieira, Renato BragaEleutério Júnior, JoséLima Júnior, Roberto César PereiraRibeiro, Ronaldo AlbuquerqueAlmeida, Paulo Roberto Carvalho
PURPOSE: To investigate E-cadherin immunoexpression during cervical carcinogenesis. METHODS: We assessed the immunohistochemical expression of E-cadherin in squamous intraepithelial lesions (SIL - 52 cases), squamous cell carcinoma (SCC) of the uterine cervix (23 cases) and also in eight cases of cervicitis. RESULTS: The results show very different E-cadherin membrane expression levels when cervicitis (88%), SILs (73%) and SCC (17%) were compared. In SILs, higher E-cadherin loss was seen in less differentiated cells in the basal third of the epithelium. This study suggests that the absence of E-cadherin expression in the membrane is a molecular event that is observed more often in SCC of the uterine cervix than in SILs or cervicitis. CONCLUSIONS: E-cadherin is an essential molecule during the process of cervical carcinogenesis and in this context exhibits a different expression pattern according to the epithelial thickness layer. .(AU)
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