Periódicos Brasileiros em Medicina Veterinária e Zootecnia

p. 5-9

The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats

Azevedo, Vera Lucia Fernandes deSantos, Paulo Sergio SantanaOliveira Jr, Gildàsio Silveira deMódolo, Gabriel PinheiroDomingues, Maria Aparecida CustódioCastiglia, Yara Marcondes MachadoVianna, Pedro Thadeu GalvãoVane, Luiz AntonioMódolo, Norma Sueli Pinheiro

PURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 RL 5 ml. that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol. RESULTS: Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury. CONCLUSION: Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion.(AU)

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